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Dr. Santanu Kar Mahapatra's profile

Name : Dr. Santanu Kar Mahapatra

Designation : Associate Professor & HOD
Qualification : M.Sc., PhD
Subject : Physiology
Department Name : Paramedical & Allied Health Science
Email ID :
Address : Egra, Municipality, Purba Medinipur - 721429

Degree name Institute Year of passing/awarded
M. Sc. in Human Physiology Vidyasagar University 2005
Ph.D. Vidyasagar University 2010
  • Worked as Assistant Professor - Research, SCBT, SASTRA Deemed University (2012-2020)
  • Worked as Research Associate III, Bose Institute, Kolkata (2010-2012)
Field of Specialization Research Area/ Areas of Interest
Immunology Macrophage polarization, Immune metabolism, TLRs
Physiology Infectious Disease (Leishmania, Tuberculosis, Malaria)
Sl no. Subject
1 Physiology, Immunology, Instrumentation, Pathology, Forensic Sciences, Nutritional Genomics, GM Foods

International Publication

Sl no. Title Author Journal Name ISBN/ISSN Page No/Internet DOI Impact Factor Year Link
1 Vitexin isolated from Prosopis cineraria leaves induce apoptosis in K-562 leukemia cells via inhibition of the BCR-ABL-Ras-Raf pathway. 4. Sarkar MK, Kar A, Jayaraman A, Kar Mahapatra S, Vadivel V. J Pharmacy Pharmacol 2022; 74(1):103-111. 2042-7158 10.1093/jpp/rgab085 2.571 2022
2 Dynamicity in Host Metabolic Adaptation Is Influenced by the Synergistic Effect of Eugenol Oleate and Amphotericin B During Leishmania donovani Infection In Vitro. Kar A, Jayaraman A, Kumar A and Kar Mahapatra S*. Front. Cell. Infect. Microbiol. 2021, 11:709316 2235-2988 10.3389/fcimb.2021.709316 5.293 2021
3 Oral combination of eugenol oleate and miltefosine induce immune response during experimental visceral leishmaniasis through nitric oxide generation with advanced cytokine demand. Kar A, Charan Raja MR, Jayaraman A, Srinivasan S, Debnath J, Kar Mahapatra S* Cytokine 146 (2021) 155623. 1043-4666 10.1016/j.cyto.2021.155623 3.861 2021
4 Anti-asthmatic effects of tannic acid from Chinese natural gall nuts in a mouse model of allergic asthma. Rajasekar N, Sivanantham A, Kar A, Mukhopadhyay S, Kar Mahapatra S, Paramasivam SG, Rajasekaran S. Int Immunopharmacol. 98 (2021) 107847. 1878-1705 10.1016/j.intimp.2021.107847 4.932 2021
5 Synergic effect of eugenol oleate with amphotericin B augments anti-leishmanial immune response in experimental visceral leishmaniasis in vitro and in vivo Kar A, Jayaraman A, Charan Raja MR, Srinivasan S, Debnath J, Kar Mahapatra S* Int Immunopharmacol. 2021; 91:107291. 1878-1705 10.1016/j.intimp.2020.107291 4.932 2021
6 Apoptotic mechanism of myricitrin isolated from Madhuca longifolia leaves in HL-60 leukemia cells. Sarkar MK, Kar A, Jayaraman A, Shanmugam K Vadivel V., Kar Mahapatra S*. Molecular Biology Reports. (2021); 48(6): 5327-5344. 1573-4978 10.1007/s11033-021-06500-z 2.316 2021
7 Pharmacokinetic properties and anti-proliferative mechanisms of vanillin against acute lymphoblastic leukemia (Jurkat) cells. Sarkar MK, Kar A, Jayaraman A, Kar Mahapatra S*, Vadivel V. South African Journal of Botany 142 (2021) 82-87. 0254-6299 10.1016/j.sajb.2021.06.016 2.315 2021
8 Oral administration of eugenol oleate cures experimental visceral leishmaniasis through cytokines abundance. Charan Raja MR, Kar A, Srinivasan S, Chellappan D, Debnath J, Kar Mahapatra S*. Cytokine.145 (2021) 155301. 1043-4666 10.1016/j.cyto.2020.155301 3.861 2021
9 Production enhancement of an anticoagulant trypsin inhibitor from Oceanimonas sp. BPMS22 and its anti‑cancer activity. Harish BS, Charan Raja MR, Kar Mahapatra S*, Uppuluri KB*. International Journal of Peptide Research and Therapeutics. 2021. 27, 197–208. 1573-3149 1.931 2021
10 Lead Generation for Human Mitotic Kinesin Eg5 using Structure-based Virtual Screening and Validation by in vitro and Cell-based Assays. Makala H, Alexandar SP, Nagarajan D, Kar Mahapatra S, Ulaganathan V Curr Comput Aided Drug Des. 2021;17(6):759-772 1573-4099 10.2174/1573409916666200722141218 1.606 2021
11 Tannic acid alleviates experimental pulmonary fibrosis in mice by inhibiting inflammatory response and fibrotic process. 10. Rajasekar N, Sivanantham A, Kar A, Kar Mahapatra S, Ahirwar R, Thimmulappa RK, Paramasivam SG, Subbiah R. Inflammopharmacology. 2020 Oct;28(5):1301-1314. 1568-5608 10.1007/s10787-020-00707-5 4.473 2020
12 Oxidative stress mediated cytotoxicity in leukemia cells induced by active phyto-constituents isolated from traditional herbal drugs of West Bengal Sarkar MK, Kar Mahapatra S,** Vadivel V.* J Ethnopharmacol. 251 (2020) 112527. 0378-8741 10.1016/j.jep.2019.112527 4.36 2020
13 Tannic acid prevents macrophage-induced pro-fibrotic response in lung epithelial cells via suppressing TLR4-mediated macrophage polarization. Sivanantham A, Pattarayan D, Rajasekar N, Kannan A, Loganathan L, Bethunaickan R, Kar Mahapatra S, Palanichamy R, Muthusamy K, Rajasekaran S. Inflamm Res. 68(12):1011-1024. 1023-3830 10.1007/s00011-019-01282-4 4.575 2019
14 Genome‐wideanalysis revealsmiR‐3184‐5pandmiR‐181c‐3p as a critical regulator for adipocytes‐associated breast cancer. Rajarajan D, Selvarajan S, Charan Raja MR, Kar Mahapatra S, Kasiappan R. J Cellular Physiology. 34(10):17959-17974. 1097-4652 10.1002/jcp.28428 6.384 2019
15 Investigation of phytochemical constituents of anti-leukemic herbal drugs used by the traditional healers of Purulia, Birbhum and Bankura districts of West Bengal. Sarkar MK, Vadivel V, Charan Raja MR, Kar Mahapatra S* Nat Prod Res. 34(23): 3388-3393. 1478-6419 10.1080/14786419.2019.1566818. 2.861 2019
16 Tannic acid protects against experimental acute lung injury through down-regulation of TLR4 and MAPK Sivanantham A, Pattarayan D, Bethunaickan R, Kar A, Kar Mahapatra S, Thimmulappa RK, Palanichamy R, Rajasekaran S J Cellular Physiology. 234(5):6463-6476 1097-4652 10.1002/jcp.27383 6.384 2019
17 Potential anti-proliferative activity of AgNPs synthesized using M. longifolia in 4T1 cell line through ROS generation and cell membrane damage Sarkar MK, Vadivel V, Charan Raja MR, Kar Mahapatra S* J Photochem Photobiol B: Biology, 186: 160-168 1011-1344 10.1016/j.jphotobiol.2018.07.014 6.252 2018
18 Eugenol derived immunomodulatory molecules against visceral leishmaniasis. Charan Raja MR, Velappan AB, Chellappan D, Debnath J,* Kar Mahapatra S,*. Eur J Med Chem., 139: 503-518. 0223-5234 10.1016/j.ejmech.2017.08.030 6.514 2017
19 ApAGP Fabricated Silver Nanoparticles Induce Amendment of Murine Macrophage Polarization. 19. Charan Raja MR, Vinod Kumar V, Varsha S, Sharmila S, Nivedha R, Roshni M, Subhashree R, Philip Anthony S, Kar Mahapatra S* J Mater Chem B, 5, 3511-3520. 2050-7518 10.1039/C6TB02095J 6.331 2017
20 Progressive Increase in Point Mutations Associates Chloroquine Resistance: Even After Withdrawal of Chloroquine use in India Das S, Tripathy S, Chattopadhayay S, Das B, Kar Mahapatra S, Hati AK, Roy S. Int J Parasitol–Drugs and Drug Resistance. 7(3):251-261. 2211-3207 10.1016/j.ijpddr.2017.06.002. 4.809 2017
21 Interaction of cadmium sulfide quantum dots with jacalin for specific recognition of cancer cells. Khan Behlol AA, Charan Raja MR, Kar Mahapatra S, Anbazhagan V J Luminescence, 182, 283–288 0022-2313 10.1016/j.jlumin.2016.10.045 3.599 2017
22 Attenuation of Mycobacterium species through direct and macrophage mediated pathway by unsymmetrical diaryl urea. Velappan AB, Charan Raja MR, Datta D, Tsai Y, Halloum I, Wan B, Kremer L, Gramajo H, Franzblau SG, Kar Mahapatra S,* Debnath J*. Eur J Med Chem., 125: 825-841. 0223-5234 10.1016/j.ejmech.2016.09.083 6.514 2017
23 Plant phenyl-propanoids conjugated silver nanoparticles from edible plant Suaeda maritima (L.) Dumort. inhibit proliferation of K562-human myeloid leukemia cells. Narendran R, Shankar S, Charan Raja MR, Brindha P, Kar Mahapatra S*, and Aravind S*. Artif Cells Nanomed Biotechnol; 45(7):1336-1342. 2169-1401 10.1080/21691401.2016.1236803 5.605 2017
24 Arene Ruthenium (II) Complexes with Chalcone, Aminoantipyrine and Aminopyrimidine Based Ligands: Synthesis, Structure and Preliminary Evaluation of Anti-leukemia Activity Pitchaimani J, Charan Raja MR, Sujatha S, Kar Mahapatra S,* Moon D,* Philip Anthony S* and Madhu V*. RSC Advances, 6, 90982-92. 2046-2069 10.1039/C6RA18504E 3.361 2016
25 Design, synthesis and in-vitro anti-leukemic evaluation of ferulic acid analogues as BCR-Abl inhibitors Narendran R, Shankar S, Charan Raja MR, Rao HMV, Subhashree R, Venkatasubramanian U, Brindha P, Kar Mahapatra S*, Aravind S*. RSC Advances, 6, 70480-4. 2046-2069 10.1039/C6RA10106B. 3.361 2016
26 Acetyl shikonin induces IL-12, nitric oxide and ROS to kill intracellular parasite Leishmania donovani in infected host. Charan Raja MR, Sujatha S, Shankar S, Narendran R, Aravind S*, Kar Mahapatra S*. RSC Advances, 6, 61777-61783. 2046-2069 10.1039/C6RA11510A 3.361 2016
27 Jacalin capped silver nanoparticles minimizes the dosage use of the anticancer drug, shikonin derivatives against human chronic myeloid leukemia Khan Behlol AA, Kar Mahapatra S, Charan Raja MR, Shankar S, Megarajan S, Narendran R, Dash SK, Haldar K, Roy S, Aravind S and Anbazhagan V RSC Advances, 6, 18980-18989 2046-2069 10.1039/C5RA27952F 3.361 2016
28 Toll-Like Receptor 2 Targeted Rectification of Impaired CD8+ T Cell Functions in Experimental Leishmania donovani Infection Reinstates Host Protection Bandyopadhyay S, Kar Mahapatra S, Paul Chowdhury B, Kumar Jha M, Das S, Halder K, Bhattacharyya Majumdar S, Saha B, Majumdar S. PLOS One., 10(11):e0142800. 1932-6203 10.1371/journal.pone.0142800 3.057 2015
29 Eugenol: A Versatile Phytomedicine. Charan Raja MR, Varsha S, Sharmila S, Kar Mahapatra S*. Int J Pharmacy Pharmaceutical Sci. 7, 35-40. 0975-1491 0.54 2015
30 Self-assembled nano fibers of betulinic acid: A selective inducer for ROS/TNFalpha pathway mediated leukemic cell death Dash SK, Chattopadhyay S, Dash SS, Tripathy S, Das B, Kar Mahapatra S, Bag BG, Karmakar P, Roy S. Bioorg Chem., 63:85-100 1090-2120 10.1016/j.bioorg.2015.09.006 5.275 2015
31 Self-assembled betulinic acid augments immunomodulatory activity associates with IgG response Dash SK, Chattopadhyay S, Tripathy S, Dash SS, Das B, Mandal D, Kar Mahapatra S, Bag BG, Roy S Biomed Pharmacother.75:205-17 1950-6007 10.1016/j.biopha.2015.07.033 6.529 2015
32 Folate decorated delivery of self assembled betulinic acid nano fibers: A biocompatible anti-leukemic therapy Dash SK, Dash SS, Chattopadhyay S, Ghosh T, Tripathy S, Kar Mahapatra S, Bag BG, Das D, Roy S. RSC Advances. 5, 24144-24157 2046-2069 10.1039/C5RA01076D 3.84 2015
33 Cobalt oxide nanoparticles induced oxidative stress linked to activation of TNF-α/caspase-8/p38-MAPK signaling in human leukemia cells Chattopadhyay S, Dash SK, Tripathy S, Das B, Kar Mahapatra S, Pramanik P, Roy S J Appl Toxicol., 35(6):603-13. 1099-1263 10.1002/jat.3080 3.446 2015
34 Double mutation in pfmdr1 gene associates emergence of chloroquine resistant Plasmodium falciparum malaria in Eastern India. Das S, Kar Mahapatra S, Tripathy S, Chattopadhyay S, Dash SK, Mandal D, Das B, Hati AK, Roy S Antimicrob Agents Chemother. 58(10), 5909–15. 1098-6596 10.1128/AAC.02762-14 5.191 2014
35 Phytopharmacological approach of free radical scavenging and antioxidative potential of eugenol and Ocimum gratissimum Linn Kar Mahapatra S,* Roy S. Asian Pac J Trop Med., 7S1, S391-7 1995-7645 10.1016/S1995-7645(14)60264-9 1.772 2014
36 A prospective strategy to restore the tissue damage in malaria infection: Approach with chitosan-trypolyphosphate conjugated nanochloroquine in Swiss mice Tripathy S, Das S, Dash SK, Kar Mahapatra S, Chattopadhyay S, Majumder S, Roy S Eur J Pharmacol., 737, 11–21. 1879-0712 10.1016/j.ejphar.2014.04.030 4.432 2014
37 Chitosan modified cobalt oxide nanoparticles stimulate TNF-α mediated apoptosis in human leukemic cells. Chattopadhyay S, Dash SK, Kar Mahapatra S, Tripathy S, Ghosh T, Das B, Das D, Pramanik P, Roy S J. Biol Inorg Chem. 19, 399–414. 1432-1327 10.1007/s00775-013-1085-2 3.358 2014
38 A novel chitosan based antimalarial drug delivery against Plasmodium berghei infection Tripathy S, Kar Mahapatra S, Chattopadhyay S, Das S, Dash SK, Majumder S, Pramanik P, Roy S Acta Tropica, 128(3):494–503 1873-6254 10.1016/j.actatropica.2013.07.011 3.112 2013
39 Miltefosine triggers a strong proinflammatory cytokine response during visceral leishmaniasis: Role of TLR4 and TLR9 Mukherjee AK, Gupta G, Adhikari A, Majumder S, Kar Mahapatra S, Majumdar SB, Majumdar S Int Immunopharmacol. April 12(4): 565–572 1878-1705 10.1016/j.intimp.2012.02.002 4.932 2012
40 Gutkha chewing induces oxidative disturbances and cellular DNA damage in humans Chakraborty SP, Kar Mahapatra S, Roy S, Roy S. Toxicological and Environmental Chemistry (2):388–402 1029-0486 10.1080/02772248.2011.639942 1.437 2012
41 In vitro time dependent vancomycin resistant Staphylococcus aureus induced free radical generation and status of antioxidant enzymes in murine peritoneal macrophage. Chakraborty SP, Kar Mahapatra S, Roy S Toxicol Mechanism Method, Jan 22(1):9–22 1537-6524 10.3109/15376516.2011.583296 2.987 2012
42 Immunomodulatory role of Ocimum gratissimum and ascorbic acid against nicotine-induced murine peritoneal macrophages in vitro. Kar Mahapatra S, Chakraborty SP, Roy S. Oxidative Medicine and Cellular Longevity. December, Volume 2011, Article ID 734319, 11 pages 1942-0994 10.1155/2011/734319 6.543 2011
43 TLR signaling mediated differential histone modification at IL-10 and IL-12 promoter region leads to functional impairments in Tumor Associated Macrophages Banerjee S, Halder K, Bose A, Bhattacharya P, Gupta G, Kar Mahapatra S, Das S, Chowdhury S, Majumdar SB, Majumdar S. Carcinogenesis, December 32(12):1789–1797. 1460-2180 10.1093/carcin/bgr208 5.702 2011
44 Prevalence of severe chloroquine resistance associates the point mutation in pfcrt and pfmdrI gene in eastern India Kar Mahapatra S, Chakraborty SP, Das S, Hati AK, Roy S. Asian Pacific Journal of Tropical Disease. Dec 1(4): 263-269 2222-1808 10.1016/S2222-1808(11)60062-5 1.32 2011
45 Internalization of Staphylococcus aureus in lymphocytes induces oxidative stress and DNA fragmentation: possible ameliorative role of nanoconjugated vancomycin. 45. Chakraborty SP, Kar Mahapatra S, Sahu SK, Das S, Tripathy S, Dash S, Pramanik P, Roy S. Oxidative Medicine and Cellular Longevity. September, Volume 2011, Article ID 942123. 1942-0994 10.1155/2011/942123 6.543 2011
46 Alteration of immune functions and Th1/Th2 cytokines balance in nicotine-induced murine macrophages: Immunomodulatory role of eugenol and N-acetylcysteine. Kar Mahapatra S, Bhattacharjee S, Chakraborty SP, Majumdar S, Roy S. Int Immunopharmacol. April, 11(4):485–495 1878-1705 10.1016/j.intimp.2010.12.020 4.932 2011
47 Nanoconjugated vancomycin: new opportunities for the development of anti-VRSA agents Chakraborty SP, Sahu SK, Kar Mahapatra S, Santra S, Bal M, Roy S, Pramanik P. Nanotechnology, March 21:105103. 1361-6528 10.1088/0957-4484/21/10/105103 3.874 2010
48 Eugenol protects nicotine-induced superoxide mediated oxidative damage in murine peritoneal macrophages in vitro. Kar Mahapatra S, Chakraborty SP, Majumdar S, Bag BG, Roy S. European Journal of Pharmacology, 623(1-3):132–140. 1879-0712 10.1016/j.ejphar.2009.09.019 4.432 2009
49 Methanol extract of Ocimum gratissimum protects murine peritoneal macrophages from nicotine toxicity by decreasing free radical generation, lipid and protein damage, and enhances antioxidant protection. Kar Mahapatra S, Chakraborty SP, Das S, Roy S. Oxidative Medicine and Cellular Longevity, September, 2(4):222–230. 1942-0994 10.4161/oxim.2.4.9000 6.543 2009
50 In vitro nicotine induced oxidative stress in mice peritoneal macrophages: a dose dependent approach. Kar Mahapatra S, Das S, Bhattacharjee S, Gautam N, Majumdar S, Roy S. Toxicology Mechanisms and Methods, Feb 19(2):100–108. 1537-6524 10.1080/15376510802255184 2.987 2009
51 Amelioratory effect of Andrographis paniculata Nees on liver, kidney, heart, lung and spleen during nicotine induced oxidative stress. Neogy S, Das S, Kar Mahapatra S, Mandal N, Roy S. Environmental Toxicology and Pharmacology, 25(3):321–328. 1382-6689 10.1016/j.etap.2007.10.034 4.860 2008
52 Oxidative stress in lymphocytes, neutrophils, and serum of oral cavity cancer patients: modulatory array of L-glutamine Das S, Kar Mahapatra S, Gautam N, Das A, Roy S. Supportive Care in Cancer, December 15 (12):1399–1405. 1433-7339 10.1007/s00520-007-0266-3 3.603 2007
Sl no. Scholar name Thesis title Co-Supervisor Status Completion year
1 Dr. Mamilla R. Charan Raja Eugenol-derived immunomodulatory molecule against experimental visceral leishmaniasis N/A 2020 Awarded
2 Dr. Amrita Kar Study of the anti-leishmanial immune response of eugenol oleate with amphotericin B and miltefosine in experimental visceral leishmaniasis N/A 2021 Awarded
3 Miss Sujatha S Isolation and characterization of biomolecules from agriculture waste product and its effect on macrophage polarization to treat visceral leishmaniasis N/A Ongoing
4 Mr. Adityan J Bioprospecting of PPI from Oceanimonas Sp. BPMS22 and its role on macrophage repolarization in the treatment of Visceral Leishmaniasis. N/A Ongoing
5 Mr. Raghunath Hazra Ongoing
6 Mr. Arijeet Samanta Ongoing
Sl no. Project title Worked as Funding Agency Amount in Rs. Duration in years Period Status
1 Bioprospecting of a protein protease inhibitor from an isolated marine bacterium Oceanimonas Sp. BPMS22 and its role on macrophage repolarization in the treatment of Visceral Leishmaniasis Principal Investigator DBT, Govt. of India 49.932 Lakh 3 2018-2021 Completed
2 Discovery and development of novel, long-acting anti-leishmanial drugs. Principal Investigator FNDR, India 65.63 Lakh 3 2017-2020 Completed
3 Study of anti-leishmanial synergic potential of miltefosine and CXCL10 Principal Investigator SERB-Young Scientist Scheme, Govt. of India 24 Lakh 3 2014-2017 Completed
Sl no. Title Organized by Venue Year
1 Visceral Leishmaniasis: Necessity of Macrophage repolarization SAVEETHA School of Engineering, Institute of Biomedical Engineering Webinar 2021
2 Eugenol Derived Immunomodulatory Molecules: A Future Prospect against Visceral Leishmaniasis International Conference On Antimicrobial Resistance, organized by CRID, SASTRA Deemed To Be University, Thanjavur SASTRA Deemed To Be University 2018
  • Indian Society of Systems for Science and Engineering (ISSE) (LM05600).
  • Society of Biological Chemist (India) (2564).
  • Indian Science Congress Association (L12490).
Sl no. Title of the Seminar/Conference/Workshop Year Role Venue Funding agency
1 National Webinar on “Online education & rural students: implications & It’s limitations” 2021 Participated Webinar N/A
2 International Webinar on “Current Trends in Neuroimmune Pharmacology” 2021 Participated Webinar N/A
3 Webinar on "mRNA Technology for Infectious Diseases: Therapeutic Applications and Vaccine Development" 2020 8. Participated Webinar by by ACS N/A
4 Webinar on “Harnessing the Tumor Immune Microenvironment” 2020 Participated Organized by Cell press N/A
5 Webinar on “Therapies and Vaccine Development for Emerging and Re-emerging Diseases” 2020 Participated Organized by Cell press N/A